Chronic kidney disease, lupus and Marfan syndrome, a connective tissue disease, can increase the risk of aortic stenosis or regurgitation. Symptoms of heart valve disease may not be noticed until many years after radiation therapy is received. Some types of cancer are treated with radiation therapy. History of radiation therapy to the chest.This life-threatening condition is usually caused by infection. Inflammation of the lining of the heart's chambers and valves, called endocarditis. ![]() If not, it's called nonrheumatic heart disease. If you have heart valve disease due to rheumatic fever, it's called rheumatic heart disease. This complication of strep throat can cause aortic stenosis, a type of heart valve disease. This increases the risk of aortic valve regurgitation. Some people are born with a missing, extra or fused valve flap.
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